|
KMID : 0380620120440030356
|
|
Korean Journal of Food Science and Technology
2012 Volume.44 No. 3 p.356 ~ p.361
|
|
|
Evaluation of Cytotoxic Properties of Caffeine Treated with Over-the-counter Drugs in the Intestinal Cells
|
|
Choi Hyun-A
Kim Mi-Ri
Park Kyung-A
Hong Jung-Il
|
|
|
Abstract
|
|
|
|
Caffeine is a xanthine alkaloid derivative found in many foods and beverages. Dietary caffeine may interact with commonly-consumed over-the-counter (OTC) drugs in body. In this study, cytotoxic effects on the intestinal cells by combined treatment of caffeine with several OTC drugs, including ibuprofen, aspirin, and acetaminophen. Cytotoxic effect of caffeine was more potent in normal intestinal INT 407 cells than in colon cancer HCT 116 cells. Relative toxicity of caffeine and the OTC drugs was significantly enhanced in INT 407 cells when treated together. Intracellular thiol levels of the cells treated with the OTC drugs increased in the presence of caffeine. When HCT 116 cells were incubated with each OTC drug after or before caffeine treatment, the relative cytotoxicity of the OTC drugs increased. The present study may provide basic information about possible health effects through the interactions between caffeine and OTC drugs in the intestinal cells.
|
|
|
KEYWORD
|
|
|
caffeine, over-the-counter drug, acetaminophen, aspirin, ibuprofen, intestinal cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|